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Kaiser Stops Providing Bextra, Citing Painkiller's Heart Attack Risk

Jan 30, 2005 | Los Angeles Times

Oakland, Calif.-based Kaiser Permanente has ordered its pharmacies to stop dispensing Bextra, a painkiller that some tests have shown increased the risk of heart attack, a spokeswoman said Saturday.

It is the first case of doctors deciding to ban use of a drug that has been approved the U.S. Food and Drug Administration, said Beverly Hayon, a spokeswoman for Kaiser.

"This is an issue of patient safety," she said.

Bextra, made by Pfizer, often is used in arthritis cases and is in the same class of drugs as other Pfizer painkillers such as Celebrex, which studies also have shown to increase chances of heart attacks and strokes. It is also in the same group of drugs as Vioxx, the drug that Merck pulled from the market last fall after its studies showed increased risk of heart attacks.

A ban by Kaiser, the nation's largest not-for-profit managed care provider with more than 9 million patients, could prompt other doctors and HMOs to avoid the drug.

That could further hurt sales of Bextra, which have declined since Pfizer said last year that the drug increased the risks of heart attacks and stroke for people who have had coronary bypass surgery. Last year, Bextra had sales of $1.26 billion.

A Pfizer spokesperson could not be reached for comment on Saturday.

Kaiser's new policy cited "significant concerns about the safety of the drug [Bextra]," and was adopted by top medical experts at Kaiser last week.

Under the new policy, "Kaiser's pharmacies in California will cease filling prescriptions for Bextra and prescribers will be contacted with suggested alternatives."

Kaiser will continue prescribing Celebrex at low doses, Hayon said.

Kaiser said its Bextra ban will take effect Tuesday for new prescriptions and March 1 for refill prescriptions.

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