Risks Posed By Crestor May Be Worse Than Previously BelievedMay 24, 2005 | www.Newsinferno.com
Although there is a risk of rhabdomyolysis (severe muscle damage) with all statin drugs, critics maintain that Crestor is, by far, the most likely to cause this condition. Public Citizen maintains that its analysis of adverse events reported to the FDA between September 2003 and September 2004 linked Crestor to incidents of rhabdomyolysis at a rate 6.2 times higher than all other statin drugs combined. The FDA has acknowledged that Crestor does pose a greater risk to Asian patients as well as patients with severe kidney disease and those taking cyclosporine. As a result, a warning to that effect was added to the Crestor label in March of this year.
Now, however, a study published in the American Heart Association journal Circulation (online 5/23/05) claims that, as among the statins, even though the incidence of rhabdomyolysis is relatively low, "Crestor has a poorer safety profile." Whether this will change the FDA’s opinion as to the safety of the drug or cause it to require a more serious warning to be placed on the label remains to be seen.