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Wall Street Journal Reports:
Vioxx Reponsible for 27,785 Heart Attacks & Merck was Aware of RisksTwo reports by the Wall Street Journal have shed light on the frequency of Vioxx side effects and what Merck actually knew about the drug's dangers. The first report was printed on October 5, 2004. The report stated that Vioxx was responsible for more than 27,000 heart attacks and sudden cardiac deaths before Merck decided to recall the drug. The Wall Street Journal report cited an unreleased study of Vioxx side effects by government regulators.
A second report by the Wall Street Journal was printed on November 1, 2004 that claimed documents exist that show that Merck hid or denied evidence for years that its blockbuster arthritis drug Vioxx causes heart problems. The report detailed specific emails and correpsondence that showed that Merck executives clearly knew about the risk of heart attack and stroke.
The report mentions a March 9, 2000 e-mail from Merck research director Edward Scolnick to colleagues conceding an elevated risk of heart attack and stroke was “clearly there." However Merck continued to try to discredit academic researchers critical of Vioxx. The Journal also reported that one training document from Merck listed potentially difficult questions about the drug and stated in capital letters, “DODGE!”
The November 1, 2004 report caused Merck shares, that were already down significantly, to drop another 10 percent as it is perceived that the company's liability for Vioxx could be huge. Additionally, Standard & Poor’s placed Merck on CreditWatch with negative implications, which sends a strong signal that the company’s debt could be downgraded within the next three months.
Vioxx Recall Timeline
Lancet Says Vioxx Should Have Been Recalled in 2000
Vioxx
Vioxx FDA Information
Where does this come from?
VIOXX (Rofecoxib) FDA INFORMATION
The FDA issued several warnings concerning Vioxx related side effects before the drug was removed from the market.. The links below will redirect you to these warnings on the FDA website.
- 2001 Merck Vioxx VIGOR Study
- 2001 Vioxx Advertising Warning Letter
- 2002 FDA Vioxx Talk Paper
- 2002 Merck Vioxx Dear Doctor Letter
- 2002 Vioxx Safety Label Update
- 2004 FDA Vioxx Recall Advisory
- 2004 FDA Vioxx COX II Q&A
- 2004 FDA Statement on Vioxx
- 2004 FDA Vioxx David Graham Statement
- 2004 Vioxx- Drug Safety Controversy
- 2005 FDA Vioxx Timeline
- 2005 FDA-Vioxx Cardiovascular Safety
Quick Facts
Vioxx Reference Guide
Generic Name
Rofecoxib
Date Approved
May 20, 1999
Manufacturer
Merck & Co.
Status
Withdrawn 9/30/04
Approved Uses
Arthritis
Muscle pain
Off Label Uses
Bone pain
Muscle pain
General pain
Serious Side Effects
Heart attacks
Blood clots
Stroke
Related Topics
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Blood Clots
Heart Attacks
Stroke
Defective Drugs
Diseases
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