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Plavix Bleeding Hemorrhaging

Plavix Side Effects Lawsuits, Heart Attacks, Internal Bleeding

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Plavix Blood Thinner Side Effects Include Cerebral and Gastrointestinal Hemorrhaging

Plavix Blood Thinner Side Effects Include Cerebral and Gastrointestinal Hemorrhaging

Plavix Blood Thinner Side Effects Include Cerebral and Gastrointestinal Hemorrhaging

Plavix is a blood thinning drug used to prevent a blood clot, stroke or heart attack. This medication, however, may also cause severe bleeding in some patients who take the drug. Numerous lawsuits across the country allege that Plavix caused complications such as cerebral hemorrhaging (brain bleeding) and gastrointestinal hemorrhaging (abdominal bleeding). These claims are supported by several research studies showing that people who take Plavix have a higher rate of bleeding events compared to those not taking the drug. These studies also found that Plavix users had a higher risk of a condition known as Thrombotic Thrombocytopenic Purpura (TTP). In many cases, Plavix cerebral and gastrointestinal bleeding is life threatening.

Plavix and Gastrointestinal Hemorrhaging

Plavix (generic: clopidogrel bisulfate) was approved in 1997 for prevention of blood clots and to reduce the risk of heart attacks and strokes. It is manufactured by Bristol-Myers Squibb and Sanofi. Plavix is the sixth top-selling drug in the U.S., with sales totaling $3.8 billion. It is often prescribed in combination with low-dose aspirin therapy to prevent heart attacks in high-risk patients.

As many lawsuits point out, Plavix's initial warning label made no mention of serious gastrointestinal bleeding. One study in the New England Journal of Medicine found that patients taking Plavix are 12 times likelier to suffer recurrent ulcers and gastrointestinal or cerebral bleeding from taking Plavix than those who received a combination of aspirin and a heartburn pill. Another study, conducted by the U.S. Centers for Disease Control and Prevention (CDC) and published in the Archives of Internal Medicine, found that the risk of hemorrhaging among Plavix-aspirin patients was significantly higher than expected. These two studies are only brief examples of research showing that Plavix is linked to a higher risk of bleeding.

Plavix and Proton Pump Inhibitors

In 2009, the U.S. Food & Drug Administration (FDA) warned that people taking Plavix should avoid a class of heartburn drug known as Proton Pump Inhibitors (PPIs), which includes drugs like Prilosec, Nexium, Prevacid, Aciphex, and Protonix. They are sometimes prescribed to reduce the risk of gastric bleeding from the Plavix-aspirin combo. The FDA warned that such drugs could inhibit the effectiveness of Plavix. Plavix does not have anti-clotting effects until it is converted or metabolized into its active form with the help of the liver enzyme CYP2C19. People who have reduced functioning of their CYP2C19 liver enzyme are unable to effectively convert Plavix to its active form.

Prilosec blocks the CYP2C19 liver enzyme, thereby reducing the effectiveness of Plavix. According to the FDA, it is unknown how other PPIs may interfere with Plavix. Other drugs that should not be used with Plavix because they may have a similar interaction with CYP2C19 include Nexium (esomeprazole), Tagamet and Tagamet HB (cimetidine), Diflucan (fluconazole), Nizoral (ketoconazole), VFEND (voriconazole), Intelence (etravirine), Felbatol (felbamate), Prozac, Serafem, Symbyax (fluoxetine), Luvox (fluvoxamine) and Ticlid (ticlopidine).

Users and State Authorities Sue over Plavix

Parker Waichman represents numerous clients in Plavix lawsuits around the country. People who are suing over the drug allege that it caused injuries such as cerebral and gastrointestinal bleeding. The lawsuits also allege that BMS and Sanofi knew about these risks, but didn’t warn consumers. Another issue is that the Plavix makers have said that Plavix is better than aspirin, a claim that is allegedly untrue and harmful since aspirin has a lower risk of complications.

Individual Plavix users are not the only ones suing over the blood thinner. In fact, the attorneys general of West Virginia and Mississippi have also alleged that the manufacturers falsely marketed Plavix. According to these lawsuits, the companies made false claims about Plavix being superior to aspirin. The lawsuits also allege that Sanofi and BMS should have known that some patients can’t properly metabolize Plavix.

Legal Help for Victims of Plavix Bleeding

If you or a loved one suffered cerebral bleeding, gastrointestinal bleeding, internal hemorrhaging or Thrombotic Thrombocytopenic Purpura (TTP) while taking Plavix, you may have valuable legal rights. To discuss your case with one of our Plavix lawyers, please fill out our online form, or call 1-800-YOURLAWYER (1-800-968-7529).

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Department of Justice Investigating Sanofi Over Plavix Disclosures

Mar 12, 2013
French pharmaceutical company Sanofi SA revealed that it is being investigated by the Department of Justice (DOJ) over disclosures to the U.S. Food and Drug Administration (FDA) about its blood-thinning drug, Plavix (clopidogrel). News of the Justice Department probe was contained in Sanofi’s recent filing with the U.S. Securities and Exchange Commission (SEC), Law360 reported. The DOJ is looking into Sanofi statements to the FDA. Sanofi said that it is cooperating with DOJ...

Compared to Aspirin Alone, Taking Plavix with Aspirin Increases Risk of Bleeding, Death and Does Not Help Prevent Second Stroke, Study Says

Aug 31, 2012 | Parker Waichman LLP
Parker Waichman LLP, a national law firm dedicated to protecting the rights of victims injured by defective drugs, is informing the public about a new study published in the August 30th issue of the New England Journal of Medicine (NEJM). In analyzing the effects of the Plavix with aspirin versus aspirin alone, the study found that the combination, referred to “dual antiplatelet therapy” did not significantly reduce the occurrence of a second stroke among patients with a...

Plavix Patient Sues After Suffering from Traumatic Bleeding Event Allegedly While Taking Plavix

Aug 21, 2012 | Parker Waichman LLP
Parker Waichman LLP, a national law firm dedicated to protecting the rights of victims injured by defective drugs, has filed a lawsuit against Bristol-Myers Squibb Company, Sanofi-Aventis U.S., L.L.S., Sanofi US Services Inc., and Sanofi-Synthelabo, Inc. The suit, which was filed on July 26th in the Supreme Court of the State of New York, County of New York (Index No. 154919/2012), alleges that Plavix caused hemorrhaging in a Maryland man. According to the Complaint, the Plaintiff took...

California Plavix User Who Suffered Gastrointestinal Hemorrhage Files Lawsuit Alleging Plavix Caused Him to Sustain Severe and Permanent Personal Injuries

Aug 16, 2012 | Parker Waichman LLP
Parker Waichman LLP, a national law firm representing people injured by defective drugs, has filed a wrongful death lawsuit on behalf of a California man who suffered a gastrointestinal hemorrhage while using Plavix. The lawsuit, which was filed in the Supreme Court of the State of New York, County of New York (Index No. 154914/2012) on July 26, 2012, alleges that the Plaintiff's injuries were caused by Plavix. According to the Complaint, the Plaintiff used Plavix from approximately...

Plavix Patient Suffers Gastrointestinal Bleeding; Files Lawsuit Alleging the Blood Thinner Caused the Hemorrhaging and Other Complications

Aug 7, 2012 | Parker Waichman LLP
Parker Waichman LLP, a national law firm dedicated to protecting the rights of victims injured by defective drugs, has filed a lawsuit on behalf of a woman who attributes her gastrointestinal hemorrhage to the use of Plavix, a blood-thinning medication manufactured by Sanofi Aventis and Bristol-Myers Squibb. The suit was filed on July 26th in the Supreme Court of the State of New York, County of New York (Index No. 154925/2012). Bristol-Myers Squibb Company, Sanofi-Aventis U.S., L.L.C., ...

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