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Proton Pump Inhibitors Associated with Kidney Disease, Research Shows

Melanie H. Muhlstock
  • Avvo
  • Proton Pump Inhibitors Associated with Kidney Disease, Research Shows

    Medications used to treat heartburn, such as Prevacid (lansoprazole), Nexium (esomeprazole), and Prilosec, (omeprazole) have been reviewed for their potential association with increased risks for kidney disease. The drugs, which are in a class of drugs known as proton pump inhibitors (PPIs), reduce acid production by blocking the stomach wall enzyme that produces acid.

    Parker Waichman LLP is pursuing lawsuits on behalf of individuals who have suffered kidney injury due to treatment with PPI medications. The firm also continues to investigate the link between PPIs and kidney disease.

    Various Research Ties PPIs to Kidney Disease

    Acid reduction helps in the prevention of esophageal, stomach, and duodenum ulcers. Should stomach juice back up into the esophagus, the PPI would render the acid less irritating and enable healing in the event of an ulcer, according to a The New York Times January 2016 report.

    Nexium, Dexilant, Prilosec, Zegerid, Prevacid, Protonix, Aciphex, and Vimovo are available by prescription to treat conditions such as gastroesophageal reflux disease (GERD), stomach and small intestine ulcers, and inflammation of the esophagus. Prilosec OTC, Zegerid OTC, and Prevacid 24HR are sold over-the-counter (OTC) for the treatment of frequent heartburn.

    Proton Pump Inhibitors Associated with Kidney Disease

    PPIs treat conditions that include gastric reflux and peptic ulcers. In an April 2016 Medscape report, the medications have been linked to various side effects, including kidney disease. While studies have long associated PPIs with an array of life-changing health reactions—fractures, dementia, heart disease, and birth defects, among others—recent studies have also suggested a PPI link to kidney disease. JAMA Internal Medicine published a study revealing that PPI use was associated with a higher risk of chronic kidney disease (CKD), according to Medscape. Researchers analyzed data from a total of over 10,400 patients and conducted a 12-year follow up. The findings were replicated in a cohort of over 248,000 patients.

    The report also indicated that PPIs are associated with acute kidney injury. In fact, research published in April 2015 compared acute kidney injury in patients who started PPIs within 120 days to those who did not. "These new concerns for CKD, acute kidney injury, and possibly dementia associated with PPIs join a long list of other concerns about side effects from PPIs. Those include decreased calcium absorption and increased fracture risk, decreased iron absorption, pneumonia, and poor magnesium absorption. There have been a number of studies in the last five years that have documented an association between chronic PPI use and hypomagnesemia, most likely due to decreased intestinal absorption. Some experts have speculated that poor magnesium absorption and hypomagnesemia predispose patients to kidney injury," Medscape also reports.

    Studies on the use of PPIs, especially in long-term use, have also tied PPIs to increases in bone fracture, pneumonia, and Clostridium difficile. For over 13 years, researchers followed 10,482 people comparing those who used PPIs to those who took a non-PPI drug in the class known as H2 receptor antagonists, such as Zantac and Pepcid. The research appears in the American Medical Association's (AMA) journal, JAMA Internal Medicine and concluded that PPI use was associated with a 20-50 percent increased risk of developing CKD. A Johns Hopkins kidney specialist noted that patients using PPIs for a longer period of time should be regularly monitored for their kidney function, according to the January 2016 The New York Times report.

    Even more evidence has tied PPI use to increased risks for developing CKD, disease progression, and end-stage renal disease (ESRD), according to an April 2016 Medical Daily report. The review of a national, comprehensive database revealed that, the greater the duration of PPI use, the greater the drugs' risk.

    "The results emphasize the importance of limiting PPI use to only when it is medically necessary, and also limiting the duration of use to the shortest duration possible," noted senior author Ziyad Al-Aly, MD, from the Veterans Administration (VA) St. Louis Health Care System in Missouri, in a news release. "A lot of patients start taking PPIs for a medical condition and they continue much longer than necessary." First author Yan Xie, MPH, also from the VA St. Louis Health Care System, and colleagues published their findings online on April 14, 2016 in the Journal of the American Society of Nephrology.

    An earlier observational study published by JAMA Internal Medicine and reported by Medscape Medical News revealed what was described as a significant 35 percent increase in chronic kidney disease risk associated with ever use of a PPI versus no PPI use.

    Parker | Waichman Logo Legal Help for Victims of PPI Who Suffered Kidney Disease
    If you, or someone you know, sustained kidney disease following use of PPI medications, you may have valuable legal rights. We urge you to contact our PPI Kidney Disease attorneys today by filling out our online form, or calling 1-800-YOURLAWYER (1-800-968-7529).


    Proton Pump Inhibitors Associated with Kidney Disease, Research ShowsRSS Feed

    Studies Link Heartburn Medications to Risk of Kidney Damage Dementia

    Sep 20, 2016
    Heartburn Medications Connected To Kidney Damage Failure Possible risks of proton pump inhibitors (PPIs) such as Prilosec, Nexium and Prevacid, may include kidney damage and dementia, research suggests. PPIs are a common class of heartburn medications that work by reducing the amount of acid produced by the stomach. The findings in recent research underscore the importance of only using PPIs when necessary to avoid any potential side effects. JAMA Neurology published a study in February...

    Studies Suggest Heartburn Medications Increase Risk of Kidney Failure

    Apr 20, 2016
    Recent research suggests that proton pump inhibitors (PPIs), a popular class of medications that include Prevacid, Prilosec, Nexium, Protonix and Aciphex, may increase the risk of kidney disease and kidney failure. PPIs are used to treat conditions including heartburn, ulcers, gastroesophageal reflux disease and acid reflux. According to a study published by the Journal of the American Society of Nephrology, patients taking PPIs have a higher risk of kidney failure and kidney disease compared...

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