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Zocor

Zocor/Simvastatin Side Effects Lawsuit, FDA Warning, Muscle Injury

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Zocor/Simvastatin Side Effect Lawsuit

Zocor/Simvastatin High Dosage Side Effects, Lawsuits | FDA Warns Increase Risk of Myopathy, Rhabdomyolysis, Muscle Injury, Skeletal Muscle Tissue Breakdown, Tenderness, Weakness, Unexplained Fatigue

United States Food and Drug Administration Press Releases about Simvastatin/Zocor Contraindications:

Zocor Side Effects

The maximum dosage (80mg) of the cholesterol-lowering drug Zocor (simvastatin) can result in an increased risk of Myopathy, a severe type of muscle injury and Rhabdomyolysis during the first 12 months of treatment as stated in a recent report released June 8, 2011 by the FDA.

The defective drug attorneys at Parker Waichman LLP are currently evaluating potential lawsuits for individuals that have experience muscle injury, skeletal muscle tissue breakdown or any of the side effects associated with taking the maximum dosage of Zocor/Simvastatin. Patients taking the highest dosage of Zocor - 80 mg - during their first year of treatment face the greatest risk of muscle injury.

At its most severe, Zocor muscle injury can lead to rhabdomyolysis, a disorder that can damage the kidneys and lead to kidney failure and possibly death. Approximately 5 out of 100,000 individuals suffering from Zocor rhabdomyolysis side effects who were prescribed the 80mg dose had to be hospitalized.

If you took Zocor or another simvastatin product and were diagnosed with myopathy or rhabdomyolysis, our Zocor muscle injury lawyers want to hear from you today. You may be able to receive compensation for you pain and suffering by filing a Zocor muscle injury lawsuit. Our Zocor muscle injury lawyers are offering victims of this drug free lawsuit evaluations, so please contact us today or call us today at 1-800-YOURLAWYER (1-800-968-7529) to protect you legal rights.

Zocor/Simvastatin Maximum Dosage Muscle Injury Warnings

According to researchers at the University of Missouri, statins such as Zocor might prevent obese patients from getting the full benefits of exercise despite the fact that this is a crucial element of preventing heart disease. The researchers conducted a study where 37 overweight, sedentary individuals between the ages of 26 and 59 were out on a 12 week exercise regimen; 18 were taking a statin. After 12 weeks, the exercise-only group had performed significantly better on two health measures compared to the statin group. Those taking a statin only increased their cardiorespiratory fitness by 1.5 percent on average while the exercise only group boosted their fitness by 10 percent. The non-statin group also did better when it came to skeletal muscle mitochondrial content, the site where oxygen is turned into energy by muscles; in the exercise-only group this increased 13 percent but in the statin group it dropped 4.5 percent.

Simvastatin Side Effects

Zocor is part of a class of drugs called statins that are used to treat high LDL (bad) cholesterol. Simvastatin is also sold in generic versions, and is an active ingredient in the combination drugs Vytorin and Simcor. Muscle injury has long been recognized as a possible statin side effect, and the labels of these medications all bear warnings regarding this risk. In 2010, the U.S. Food and Drug Administration (FDA) updated the labels of high-dose simvastatin to warn of an association with muscle injuries.

On June 8, 2011, the FDA added new warnings to the labels of Zocor and other simvastatin (cholesterol-lowering) drugs and recommended that patients not be prescribed the 80 mg dose during the first 12 months of treatment in order to mitigate the Zocor muscle injury risk. The new restrictions and warnings also apply to Vytorin and Simcor. In addition, the labels for simvastatin, Vytorin and Simcor were changed to include new dosing recommendations when these drugs are used with certain medications, such as blood pressure medicines amlodipine and diltiazem, which interact to increase the level of simvastatin in the body, which can increase the risk for myopathy.

The FDA's action was prompted by a seven-year study and patient reports that prove those taking the higher dosage of simvastatin have a greater risk of muscle injury than patients treated with lower doses or other statins. The agency said its review of a trial called the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) revealed 52 cases of myopathy occurring in the group of patients treated with 80 mg simvastatin versus one in the group treated with 20 mg. Twenty-two patients in the 80-mg group developed rhabdomyolysis, while none in the 20-mg group developed the disorder.

The risks for myopathy and rhabdomyolysis with simvastatin 80 mg were highest in the first 12 months of treatment, 5 per 1000 person-years and 2 per 1000 person-years, respectively, and decreased to 1 per 1000 person-years and 0.4 per 1000 person-years after that, the FDA said.

An analyses of the FDA's Adverse Event Reporting System (AERS) database also showed that the level of reporting of fatal rhabdomyolysis associated with the 80-mg dose of simvastatin has been higher in comparison with lower doses of simvastatin or lower doses of most other statins, the agency said.

Zocor May Counteract the Benefits of Exercise in Obese Patients

According to researchers at the University of Missouri, statins such as Zocor might prevent obese patients from getting the full benefits of exercise despite the fact that this is a crucial element of preventing heart disease. The researchers conducted a study where 37 overweight, sedentary individuals between the ages of 26 and 59 were out on a 12 week exercise regimen; 18 were taking a statin. After 12 weeks, the exercise-only group had performed significantly better on two health measures compared to the statin group. Those taking a statin only increased their cardiorespiratory fitness by 1.5 percent on average while the exercise only group boosted their fitness by 10 percent. The non-statin group also did better when it came to skeletal muscle mitochondrial content, the site where oxygen is turned into energy by muscles; in the exercise-only group this increased 13 percent but in the statin group it dropped 4.5 percent.

Legal Help for Victims of Zocor Muscle Injuries

If you suffered from myopathy or rhabdomyolysis because of Zocor, you have valuable legal rights. To find out how our Zocor injury lawyers can help you receive compensation for your injuries, please fill out our online form or call 1-800-YOURLAWYER (1-800-968-7529) today.

Study Finds that Statins may Stall Exercise Benefits in Obese Adults

May 23, 2013
Statins, drugs prescribed to reduce blood cholesterol levels, may actually minimize exercise benefits in obese adults, a new study reported. Statins are considered best-selling drugs worldwide and are prescribed to people diagnosed with obesity, diabetes, and metabolic syndrome, which is a dangerous health condition that includes excess body fat and/or high blood pressure, high blood sugar, and/or high cholesterol, according to Medical News Today. Statins are prescribed to reduce cholesterol...

Statin Drugs May Increase Risk for Cataracts, Especially in Diabetics

Jan 1, 2012 | Parker Waichman LLP
People suffering from type 2 diabetes are more likely to suffer an age-related cataract if they are taking a statin drug to lower cholesterol levels. According to a HealthDay News report on a new study from University of Waterloo in Canada, diabetics taking statin drugs are more likely to suffer a cataract than those who weren’t taking one of these cholesterol drugs. Overall, the study authors still believe there is still a clinical benefit to a person suffering from type 2 diabetes who...

Study Sees Diabetes Risk with High-Dose Statins, Fewer Benefits from Zocor

Jun 23, 2011 | Parker Waichman LLP
A new study is providing yet another reason to avoid high-dose Zocor.  The study, conducted by researchers in the U.K., has found that high doses of statins, including Zocor and its generic equivalent, simvastatin, are associated with an increased risk of diabetes.  The same study also found that 80 mg of simvastatin was not as effective at reducing heart risks compared to the same dose of Lipitor.Earlier this month, the U.S. Food & Drug Administration (FDA) restricted the use of...

"Do Not Use" 80 mg Zocor, Public Citizen Says

Jun 13, 2011 | Parker Waichman LLP
If you use Zocor (simvastatin) 80 mg, the consumer group Public Citizen says you should talk with your doctor about switching to a lower dose or a different medication all together.  Public Citizen placed 80 mg Zocor - the highest recommended dose - on its "Do Not Use" list after the U.S. Food & Drug Administration (FDA) placed dosage restrictions on the statin due to its association with myopathy (severe muscle injury), including it's most severe form, rhabdomyolysis. “We...

Citing Muscle Risks, FDA Restricts Highest Zocor Dose

Jun 9, 2011 | Parker Waichman LLP
Patients taking the statin Zocor (simvastatin) should not be given the highest 80 mg dose in their first year of treatment, according to the U.S. Food & Drug Administration (FDA).  The agency's review of a clinical trial, as well as an analysis of its adverse even reports prove that such patients face the highest risk of suffering myopathy (severe muscle injury), including it's most severe form, rhabdomyolysis.Zocor 80 mg should be used only in patients who have been taking this dose...

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