Parker Waichman LLP

Tysabri Brain Infection Risk

Risk of Brain Infection With Multiple Sclerosis Drug Tysabri. The risk of developing a potentially fatal brain infection is higher than previously thought for patients taking the genetically engineered multiple sclerosis drug Tysabri (natalizumab), scientists reported this week. Tysabri, made by Biogen, is prescribed for patients with relapsing multiple sclerosis, the most common form of […]

Multiple Sclerosis Drug Tysabri

Risk of Brain Infection With Multiple Sclerosis Drug Tysabri. The risk of developing a potentially fatal brain infection is higher than previously thought for patients taking the genetically engineered multiple sclerosis drug Tysabri (natalizumab), scientists reported this week.

Tysabri, made by Biogen, is prescribed for patients with relapsing multiple sclerosis, the most common form of the disease. The drug is administered intravenously every 28 days, Newsday reports. In multiple sclerosis, the immune system assaults the protective coating (myelin) surrounding nerve fibers, damaging them, and causing patients to suffer weakness and lose vital functions. Tysabri helps to ward off attacks.

A new medical investigation reports that in some patients Tysabri can cause a tenfold risk of developing antibodies to the John Cunningham (JC) virus. The virus can lead to a potentially fatal brain disorder known as progressive multifocal leukoencephalopathy, or PML. A German research team, reporting in the journal Neurology Neuroimmunology and Neuroinflammation said the PML risk is higher than previously thought, Newsday reports. The study, led by Dr. Heinz Wiendl (University of Münster, Germany), was published online on January 27, 2016.

Physicians and Groups Said Multiple Sclerosis Drug Tysabri Good

Physicians and advocacy groups said Tysabri is a good treatment option despite the findings and they emphasized the importance of routine screening of patients taking the drug. Dr. Patricia K. Coyle, vice chair of neurology at Stony Brook University Hospital and director of the hospital’s MS Comprehensive Care Center, said, “Whenever you manipulate the immune system, then theoretically the person may be at risk for PML,” according to Newsday. Dr. Coyle said if any of her patients develop elevated antibody levels, she would advise them about other medication choices. But for those who remain free of JC virus-related antibodies and are doing well on Tysabri, she will continue the drug.

Dr. Coyle said the JC virus is present in a vast swath of people worldwide. According to the new research, Tysabri aids the virus’s capacity to breach the blood-brain barrier and cause PML, according to Newsday. There is no cure for PML. Dr. Paul Wright, who chairs the departments of neurology at North Shore University Hospital in Manhasset and Long Island Jewish Medical Center in New Hyde Park, explains, “We all harbor this virus and we all have the propensity to have the virus.” When the immune system is compromised, the virus can come out and be manifested.

Many people who take Tysabri had not fared well on other therapies for multiple sclerosis

Many people who take Tysabri had not fared well on other therapies for multiple sclerosis, doctors said. Biogen, maker of Tysabri, has posted a warning on its website about the medication’s propensity to induce PML.

“This study emphasizes the need for vigilant monitoring of people with MS taking natalizumab, including regular antibody testing, MRI monitoring to improve detection of PML, and clinical monitoring for early signs suggesting the possibility of PML,” noted Dr. Bruce A. Cohen, a professor in neurology and clinical neurosciences at Northwestern University’s Feinberg School of Medicine, and Chair of the National MS Society’s National Medical Advisory Committee. Dr. Cohen said natalizumab is a very effective therapy for relapsing MS, and the decision to discontinue this therapy needs to balance the risk of PML against their risk of worsening MS, and the potential adverse effects and efficacy of alternate therapies.

Need Legal Help Regarding Multiple Sclerosis Drug Tysabri?

The personal injury attorneys at Parker Waichman LLP offer free, no-obligation case evaluations. For more information, fill out our online contact form or call 1-800-YOURLAWYER (1-800-968-7529).

What Our Clients Say About Us
We have worked with thousands of clients and we appreciate them and their positive reviews. Here are just a few recent client reviews...
5 Star Reviews 150
We are very thankful to Parker Waichman for their expert guidance in our legal matter. We worked primarily with Benita Rollis who was extremely professional, supportive and always available to answer our questions and assist us in any way she could. We had a positive outcome and could not have done it without Benita and this firm helping us every step of the way!!!
janet adkins
a year ago
5 Star Reviews 150
They did their job. Thank you great professional highly recommend them
Donald Brown
4 years ago
5 Star Reviews 150
Positive: Professionalism , Quality , Responsiveness , Value MY CONTACT PARALEGAL WAS TINA MORACE, SHE WAS WAY BEYOND FANTASTIC IN ALWAYS KEEPING ME UPDATED WITH THE STATUS OF MY 911 VICTIMS RELIEF FUND CASE STATUS.
TONY P
6 months ago

Why Choose Us to Help You?

We Take Care of Everything
Your situation is stressful enough: Let us take on the deadlines, paperwork, investigation, and litigation. We'll handle every detail so you don't have to worry.
No Recovery = No Legal Fees
We work on a contingency-fee basis, meaning that we only get paid from a portion of your settlement or jury award. If you don't get compensation, you owe us nothing.
Decades of Experience
Your situation is stressful enough: Let us take on the deadlines, paperwork, investigation, and litigation. We'll handle every detail so you don't have to worry.
Respected by Our Peers
Judges, insurance adjusters, and fellow attorneys all speak highly of our skills, and we've earned numerous accolades, including a flawless rating from AVVO.
We Have Many Locations To Serve You
We have the experience and the skilled litigators to win your case. Contact us and speak with a real attorney who can help you.
Long Island – Nassau
Parker Waichman LLP
6 Harbor Park Drive
Port Washington, NY 11050
Long Island – Suffolk
Parker Waichman LLP
201 Old Country Road – Suite 145
Melville, NY 11747
New York
Parker Waichman LLP
59 Maiden Lane, 6th Floor
New York, NY 10038
Queens
Parker Waichman LLP
118-35 Queens Boulevard, Suite 400
Forest Hills, NY 11375
Brooklyn
Parker Waichman LLP
300 Cadman Plaza West
One Pierrepont Plaza, 12th Floor
Brooklyn, NY 11201
New Jersey
Parker Waichman LLP
80 Main Street, Suite 265
West Orange, NJ 07052
Florida
Parker Waichman LLP
27299 Riverview Center Boulevard
Suite 108
Bonita Springs, FL 34134
Nationwide Service
Parker Waichman LLP
59 Maiden Lane, 6th Floor
New York, NY 10038