Parker Waichman LLP

Tarceva Label Updated After Reports of Liver Failure, Deaths

Tarceva, a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer, has been linked to several instances of liver failure and hepatorenal syndrome in some patients taking the drug. Tarceva, known generically as erlotinib, is in a class of drugs known as epidermal growth factor receptor (EGFR) tyrosine […]

<"https://www.yourlawyer.com/practice_areas/defective_drugs">Tarceva, a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer, has been linked to several instances of liver failure and hepatorenal syndrome in some patients taking the drug.

Tarceva, known generically as erlotinib, is in a class of drugs known as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. These treatments are designed to block the EGFR protein, believed to play a role in cancer cell growth. Tarceva monotherapy is indicated for the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen; Tarceva in combination with gemcitabine is indicated for the first-line treatment of patients with locally advanced, unresectable, or metastatic pancreatic cancer.

Today’s Tarceva warning was prompted by information obtained from a pharmacokinetic  study in patients with advanced solid tumors and moderate hepatic impairment.  In this study, 10 of the 15 patients died on treatment or within 30 days of the last Tarceva dose. Although 8 of these patients died from progressive disease, one patient died from hepatorenal syndrome and one patient died from rapidly progressing liver failure.

According to the Food & Drug Administration (FDA),  patients with hepatic impairment should be monitored closely during therapy with Tarceva, and dosing should be interrupted or discontinued if changes in liver function are severe.

Several changes have been made to  the Tarceva label to communicate this new safety information.  In the PRECAUTIONS section of the label, sections entitled “Patients with Hepatic Impairment”, “Hepatotoxicity” and “Renal Failure” have been updated with relevant information and moved to the WARNINGS section.  The DOSAGE AND ADMINISTRATION section has also been updated.

What Our Clients Say About Us
We have worked with thousands of clients and we appreciate them and their positive reviews. Here are just a few recent client reviews...
5 Star Reviews 150
i am glad to give a 5 star review for parker waichman and the absolute competent...consummate professional ms. benita rollis. she is capable, friendly and patient and has seen me through the entire process...i am giving 5 stars because of the limit shown above but she has performed at a 10 star level....kudos to ms. rollis and pw ...thanks for all
larry howard
3 years ago
5 Star Reviews 150
Positive: Professionalism , Responsiveness How does one improve upon a professional team? Perhaps more interaction with the attorney necessary, but paralegals are quite competent.
Gordon Wilson
3 years ago
5 Star Reviews 150
I would like to thank both Benita Rollis and Shelly Davis for the wonderful job that they have done for me. They made it easy and helped through the hard times. Thank you both. Steven Lubowsky
Steven Lubowsky
a year ago

Why Choose Us to Help You?

We Take Care of Everything
Your situation is stressful enough: Let us take on the deadlines, paperwork, investigation, and litigation. We'll handle every detail so you don't have to worry.
No Recovery = No Legal Fees
We work on a contingency-fee basis, meaning that we only get paid from a portion of your settlement or jury award. If you don't get compensation, you owe us nothing.
Decades of Experience
Your situation is stressful enough: Let us take on the deadlines, paperwork, investigation, and litigation. We'll handle every detail so you don't have to worry.
Respected by Our Peers
Judges, insurance adjusters, and fellow attorneys all speak highly of our skills, and we've earned numerous accolades, including a flawless rating from AVVO.
We Have Many Locations To Serve You
We have the experience and the skilled litigators to win your case. Contact us and speak with a real attorney who can help you.
Long Island – Nassau
Parker Waichman LLP
6 Harbor Park Drive
Port Washington, NY 11050
Long Island – Suffolk
Parker Waichman LLP
201 Old Country Road – Suite 145
Melville, NY 11747
New York
Parker Waichman LLP
59 Maiden Lane, 6th Floor
New York, NY 10038
Queens
Parker Waichman LLP
118-35 Queens Boulevard, Suite 400
Forest Hills, NY 11375
Brooklyn
Parker Waichman LLP
300 Cadman Plaza West
One Pierrepont Plaza, 12th Floor
Brooklyn, NY 11201
New Jersey
Parker Waichman LLP
80 Main Street, Suite 265
West Orange, NJ 07052
Florida
Parker Waichman LLP
27299 Riverview Center Boulevard
Suite 108
Bonita Springs, FL 34134
Nationwide Service
Parker Waichman LLP
59 Maiden Lane, 6th Floor
New York, NY 10038