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Injured by Actos?

Actos is a newer class of diabetes drugs called thiazolidinediones or glitazones, which increase the body's sensitivity to insulin. The FDA (Food & Drug Administration) approved Actos on July 15, 1999. Actos is manufactured by Takeda Chemical Industries.

The first approved drug in the class, Rezulin, was taken off the market in 2000 after it was linked to dozens of cases of fatal liver disease. Avandia is another drug that is a thiazolidinediones or glitazones.

The American Heart Association and American Diabetes Association issued recommendations to guide the use of Actos, a glucose-lowering drugs and other as thiazolidinediones (TZDs). Diabetics who have mild heart disease or any problems with their kidneys may be at an increased risk of developing congestive heart failure if they take certain diabetes medications, according to a new study.

The study, published in the September 9, 2003 issue of the Mayo Clinic Proceedings, reported on six cases of congestive heart failure in people taking pioglitazone (Actos) or rosiglitazone (Avandia) to help control their diabetes. The researchers studied the records of six men, between the ages of 66 and 78 years, with type 2 diabetes who had gone to the emergency room at Dallas Veterans Affairs Medical Center emergency room.

All six patients complained of shortness of breath, swelling of their feet, and weight gain, which are symptoms of congestive heart failure and pulmonary edema (fluid buildup in the lungs). Congestive heart failure occurs when the heart can no longer pump enough blood to maintain adequate circulation. Because the heart doesn't pump properly, fluid often builds up in the lungs.

Four of the six people in this study had chronic renal insufficiency, which means that their kidneys weren't functioning normally. Only two had any previous signs of heart disease. Four of the six had high blood pressure. They had been on the diabetes medications for between one month and 16 months. Three people developed symptoms within one to three months after the dose of their diabetes drug had been increased.

If you or a loved one took Actos and suffered side effects, please fill out the form at the right for a free case evaluation by a qualified drug side effects attorney.

Women Face Fracture Risk from Avandia, Actos, Study Finds

Feb 16, 2010 | Parker Waichman Alonso LLP
Another study has linked thiazolidinediones, a class of diabetes drugs which include Avandia and Actos, with a higher risk of bone fractures, specifically in women. This  study was conducted by the Center for Health Services Research at Henry Ford Hospital and published in the February issue of the Journal of Clinical Endocrinology & Metabolism.Fractures are just one of a growing number of problems associated with medications like Avandia and Actos, and previous research has found that...

Class Of Diabetes Drugs That Includes Avandia Linked To Fracture Risk

Sep 30, 2009 | Parker Waichman Alonso LLP
The risk of bone fracture in individuals taking thiazolidinediones  has again been suggested in another recent study. Science Daily just reported that research published this week in PLoS Medicine discussed the risk between the type 2 diabetes drugs  and bone fracture. Thiazolidinediones—known as TZDs—were introduced in the 1990s and include such popular medications as Avandia (rosiglitazone) or Actos (pioglitazone).The study, led by Ian Douglas of the London School of...

FDA Wants New Diabetes Drugs Tested for Heart Risks

Dec 18, 2008 | Parker Waichman Alonso LLP
New diabetes drugs will now have to be screened for heart risks before they can be approved, the Food & Drug Administration (FDA) said yesterday.  The new testing standards do not apply to drugs already on the market, including Avandia and Actos, two medications that have been linked to heart problems.According to the FDA, more than 23 million people in the United States have been diagnosed with type 2 diabetes or diabetes mellitus, a chronic metabolic disorder characterized by...

Avandia, Actos Raise Fracture Risk for Women

Dec 10, 2008 | Parker Waichman Alonso LLP
Women who take the diabetes drugs Avandia and Actos face a higher risk of bone fractures, a new study has found.  The fracture problem is just the latest troubling side effect associated with these drugs, which have also been linked to heart problems.For the study, researchers at North Carolina's Wake Forest University School of Medicine  and the University of East Anglia in Britain analyzed 10 previous clinical studies lasting at least a year involving 14,000 patients. ...

Avandia Linked with Increased Risk of Death, Heart Attacks

Nov 25, 2008 | Parker Waichman Alonso LLP
According to a study published in a recent issue of the Archives of Internal Medicine, the diabetes drug rosiglitazone maleate—also known as Avandia—may increase the risk of certain cardiovascular events. The study, which was conducted by Dr. Wolfgang Winkelmayer of Brigham and Women's Hospital in Boston and colleagues,  involved patients aged 65 and older who had taken either Avandia or Actos (pioglitazone hydrochloride) for one year. Both Avandia and Actos belong to the same...

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