Parker Waichman LLP

Study Finds “Robust” Risk of C. difficile with Proton Pump Inhibitors, other Heartburn Drugs

A new study has found that taking acid reducing drugs, including proton pump inhibitors, can significantly increase the risk for Clostridium difficile (C. difficile) infection. The lead author of the study, which involved a meta-analysis of 30 separate studies, characterized the association between C. difficile and proton pump inhibitors and other heartburn drugs seen in […]

Study Finds "Robust" Risk of C. difficile with Proton Pump Inhibitors, other Heartburn DrugsA new study has found that taking acid reducing drugs, including proton pump inhibitors, can significantly increase the risk for Clostridium difficile (C. difficile) infection. The lead author of the study, which involved a meta-analysis of 30 separate studies, characterized the association between C. difficile and proton pump inhibitors and other heartburn drugs seen in the analysis as “robust.”

Proton pump inhibitors are used to treat conditions such as gastroesophageal reflux disease (GERD), stomach and small intestine ulcers, and inflammation of the esophagus. Over-the-counter proton pump inhibitors are used to treat frequent heartburn are sold under the names:

  • Dexilant (dexlansoprazole)
  • Nexium (esomeprazole magnesium)
  • Prevacid (lansoprazole) and OTC Prevacid 24hr
  • Prilosec (omeprazole) and Prilosec OTC
  • Protonix (pantoprazole sodium)
  • Vimovo (esomeprazole magnesium and naproxen)
  • Zegerid (omeprazole and Sodium bicarbonate) and Zegerid OTC

Previous studies have indicated that use of proton pump inhibitors could increase the risk for C. difficile. In a Drug Safety Communication issued in February, the U.S. Food & Drug Administration (FDA) warned that taking proton pump inhibitors may be associated with the occurrence of Clostridium difficile–associated diarrhea (CDAD), a severe form of diarrhea caused by C. difficile bacteria. At the time, the agency said it was working with manufacturers to include information about the increased risk of CDAD with use of proton pump inhibitors in the drug labels.

This new meta-analysis included studies published through January 2012 out of the U.S., U.K., Canada, and Israel. Twenty-four studies were from single centers, five were multicenter, two were from general practice research databases, and one was from a general practice clinic. Five studies exclusively addressed community-acquired C. difficile 24 addressed hospital-acquired infection, 1 covered both community- and hospital-acquired C. difficile and 1 examined infection rates in a long-term care facility.

Each of the separate analyses showed a significant association between acid suppression and C. difficile, with pooled effect estimates of 1.67 for studies looking at proton pump inhibitors. For H2 blocker, sthe estimate was 1.44.

Why proton pump inhibitors and similar drugs might be increasing the risk for C. difficile wasn’t clear, as gastric acid does not kill C. difficile spores. However, it does kill the vegetative form of the bacteria. The study authors also pointed out that acid suppression therapy has also been shown to delay gastric emptying, which could improve survival of the vegetative form of C. difficile.

What Our Clients Say About Us
We have worked with thousands of clients and we appreciate them and their positive reviews. Here are just a few recent client reviews...
5 Star Reviews 150
No improvement needed. Service was great keeping me well informed step by step during the process.
Anthony Striffolino
7 years ago
5 Star Reviews 150
I had a wonderful experience with ms burgess an will deal with this company again.
Butter Fly
a year ago
5 Star Reviews 150
Joanne M. Stevens nurse at Parker and Wakeman has been very helpful knowledgeable and tentative to my case. I have questions she has answers she addresses all my concerns. The world needs more case managers like her. Bottom line great nurse, great service, highly recommended. AAA+!+
Lewis
5 years ago

Why Choose Us to Help You?

We Take Care of Everything
Your situation is stressful enough: Let us take on the deadlines, paperwork, investigation, and litigation. We'll handle every detail so you don't have to worry.
No Recovery = No Legal Fees
We work on a contingency-fee basis, meaning that we only get paid from a portion of your settlement or jury award. If you don't get compensation, you owe us nothing.
Decades of Experience
Your situation is stressful enough: Let us take on the deadlines, paperwork, investigation, and litigation. We'll handle every detail so you don't have to worry.
Respected by Our Peers
Judges, insurance adjusters, and fellow attorneys all speak highly of our skills, and we've earned numerous accolades, including a flawless rating from AVVO.
We Have Many Locations To Serve You
We have the experience and the skilled litigators to win your case. Contact us and speak with a real attorney who can help you.
Long Island – Nassau
Parker Waichman LLP
6 Harbor Park Drive
Port Washington, NY 11050
Long Island – Suffolk
Parker Waichman LLP
201 Old Country Road – Suite 145
Melville, NY 11747
New York
Parker Waichman LLP
59 Maiden Lane, 6th Floor
New York, NY 10038
Queens
Parker Waichman LLP
118-35 Queens Boulevard, Suite 400
Forest Hills, NY 11375
Brooklyn
Parker Waichman LLP
300 Cadman Plaza West
One Pierrepont Plaza, 12th Floor
Brooklyn, NY 11201
New Jersey
Parker Waichman LLP
80 Main Street, Suite 265
West Orange, NJ 07052
Florida
Parker Waichman LLP
27299 Riverview Center Boulevard
Suite 108
Bonita Springs, FL 34134
Nationwide Service
Parker Waichman LLP
59 Maiden Lane, 6th Floor
New York, NY 10038